MDM2 Suppresses p73 Function without Promoting p73 Degradation
نویسندگان
چکیده
منابع مشابه
MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function
The protein p73, a homologue of the tumor suppressor protein p53, is capable of inducing apoptosis and cell cycle arrest. MDM2 is transcriptionally activated by p73 and represses the functions of p73, including p73-dependent transactivation and growth suppression. However, the molecular mechanism of this repression is unknown. In this study, we show that MDM2 mediates p73 ubiquitination. MDM2 m...
متن کاملp73 expression and function in vestibular schwannoma.
OBJECTIVES To determine the expression of the p53 family member p73 in vestibular schwannoma (VS) and to determine the potential role of this tumor suppressor in regulating the proliferation of HEI193, a human papillomavirus E6-E7 immortalized VS cell line. METHODS Immunohistochemical staining was used to investigate the expression of p73 in 34 cases of archived VS tissue, while Western blot ...
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The development of multicellular organisms requires a balance between the cellular processes of proliferation, differentiation and death. These processes are important throughout the whole life of the organism. Daily, the DNA in our cells is under attack by agents that can cause damage. Thus, the cells have developed mechanisms to manage the DNA damage through activation of pathways leading to ...
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p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic act...
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The transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolved problem. In this work, we have determined the first crystal structures of p73 DNA-binding domain tetramer bound to response elements with spacers of different length. The str...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1999
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.19.5.3257